Players can assemble their crew in various ways to improve battle tactics, choosing from over 40 characters. The game also provides the option of playing the story arc through the differing perspectives of Ace, Luffy, Akainu, or Whitebeard. This will grant players a fresh new perspective on the story with each playthrough.

Burning Blood is the first of 38 One Piece games to be offered on a Microsoft console. Until now, One Piece games were primarily playable on PlayStation and various Nintendo consoles. The series contains mostly RPGs and fighting games. Burning Blood fits the latter category. The game is also available on PlayStation 4, PS Vita, and PC.